Fitzpatrick Dry Granulation Machines and Equipment

Dry granulation is a bulk powder mixing technique that enhances the flow of powder, creates uniform mixtures, reduces powder segregation and creates dust-free formulations.

The Fitzpatrick Company has long been recognized as a worldwide leader in the manufacture of dry granulation machines. Pharmaceutical companies, food processors, and chemical manufacturers use our versatile dry granulation equipment to improve dry powder compaction, milling and screening with an eye toward more efficient processing and more consistent product quality.

Advantages of Dry Granulation

Dry granulation offers numerous advantages for powder mixing:

  • Improve bulk powder mix flow properties
  • Improve compact uniformity and powder density
  • Minimize the degree of ungranulated material
  • Prevent segregation of ingredients in the powder mix
  • Improve powder compressibility
  • Enhance product containment
  • More efficient pharmaceutical tableting

For these very reasons, a pharmaceutical dry granulator is a critical component of pharmaceutical R&D and production scale-up infrastructure. 

Learn more about the advantages of pharmaceutical roll compactors and pharmaceutical hammer mills from the Fitzpatrick Company.

Roller Compactor Machines for Dry Granulation

Using a roller compactor machine, fine powders are pressed between two rotating rolls or drums, compressing the powders into ribbons or sheets that can be milled to achieve uniform granule sizes.

Roller compactors for dry compaction are ideal for moisture-sensitive and heat-sensitive formulations. The roller compactor dry compaction method requires no liquid binders, no high temperature drying, and produces uniform granules with less energy.

The Fitzpatrick Company offers several models of roller compactor machines, each of which can be configured to your application needs. Our models include:

Hammer Mills for Dry Granulation

Hammer mills are the dry granulator of choice for particle size reduction and other milling applications. In fact, our Scalable Lab System™ is a modular system that allows you to alternate between five milling solutions in mere seconds. We also offer a range of production-scale industrial hammer mills for dry granulation.

The Dry Granulation Process

The dry granulation method is a far simpler and more efficient process, when compared to wet granulation. 

Whereas wet granulation requires wet massing, screening of granules, drying, and compression — a time-consuming and costly process — the dry granulation process involves no water or granulating fluid. 

Ultimately, the material properties of your formulation will dictate the appropriate granulation method. 

Dry granulation is preferred when using heat- or moisture-sensitive ingredients; dry granulation offers stability during processing for these formulations. The dry granulation method is also preferable when low moisture is necessary to ensure a long shelf-life for the product, or for quick-release pharmaceutical tablets.

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Principles of Roll Compaction & Granulation

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