Particle Size Reduction

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Particle size reduction (also known as comminution) is commonly used to improve material properties, including a more desirable particle size distribution and increased surface area – resulting in better particle flowability, reactivity, drying, bulk density and compactability, to name a few.

Dry milling of pharmaceutical powders is an integral step in the tableting process, where size reduction equipment is utilized to achieve particle sizes that will improve a tablet’s dissolution, active ingredient content uniformity, effective drug efficacy extraction, enhanced absorption rates, bioavailability and physical stability.

Comminution in the form of impact milling, is chosen based on not just the properties of the feed material (i.e. initial particle size/shape, moisture content, temperature sensitivity, hardness, grindability, or other physical and chemical properties), but also on the versatility of the size reduction equipment – such as safety, containment, operator exposure levels and cleanability.

Every comminution application is different. Size reduction equipment that works well with one material may not work well with another similar material. Selecting the correct dry milling process ultimately depends on your finished product’s required size range and your raw material’s size and friability. Once you determine the size range of your finished product, we help you test the primary processing characteristics of your raw material and help you choose the correct particle size reduction equipment.

Size Reduction Resources | Downloads

The Size Reduction Process & Comminution Systems

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